Idolobha laseZacatecas liphethe intaba ephakeme engu-2,667 m enedwala elikhulu eliphilayo elibizwa ngeLa Bufa. Ukubalwa kukaSantiago de la Laguna, uDon José de Rivera Bernárdez, isazi-mlando sedolobha futhi ozinikele kuVirgin, wayenombono omuhle wokwakha indlu yesonto egqumeni laseLa Bufa, lapho kwakuzokhonzwa khona isithombe soBusisiwe njengokuvezwa kwepulasitiki kwemicimbi eyaqala umlando omuhle weZacatecas, ngoSepthemba 8, 1546.
UCount Rivera wakha futhi wanikezela iSahluko seLa Bufa, nesihloko esithi Patronage, ukukhumbula ukuthi lapho abaseSpain babehlala khona ebukhosini babo kwakulapho abomdabu babenamandla khona. Isonto lenze imisebenzi ebalulekile yokubuyiselwa futhi lavulwa kabusha ngo-1729.
Mayelana nemvelaphi yeVirgin, enkulu kakhulu futhi enobukhulu obuhle, kunezinhlobo ezintathu: umpristi uBezanilla y Mier ubala ukuthi uDon Diego de Ibarra wamletha ebuthweni lakhe. UJosé de Refugio Gasca - naye oyi-prebistero - uphinda lokhu okungenhla futhi uveza ukuthi yiNkosi uFelipe II, owayithumela, kanti u-Ernesto de la Torre uthi kwakuyisipho esenziwa ngo-1586 yiReal de Minas nguMbhishobhi waseGuadalajara. Yize kunezindaba eziningana maqondana nemvelaphi yayo, ngakho-ke iNcasakazi yasePatrocinio iyisithombe esiya ekukhonzeni, esigxilisa imizwa yokuzinikela futhi sigcwele induduzo.
Ekufeni kuka-Count of Santiago de la Luna (1762), owayephethe ukunakekelwa kwethempeli, umngcwabo wendlu engcwele "walingwa ngudeveli" weba isithombe seNtombi nto wabalekela edolobheni. Lapho enza ukuhlambalaza izinsimbi zawo wonke amasonto zaqala ukukhala ngaphandle kokungenela kwezinsimbi, egcwele ukwesaba wabeka isithombe eminyango yesonto laseLos Remedios.
Kuze kwaba ngoSepthemba 10, 1795 lapho udwendwe olukhulu lwashiya isonto lakwaMerced eliholele isithombe esontweni lalo. Kufanele kuqhakanjiswe i-façade yayo ekuqaleni kwe-baroque yekhulu le-18, ekhombisa iNcasakazi ngokukhululeka okuphezulu nengane engalweni yayo, izungezwe yimisebe, ngemuva kwamatshe anezitshalo ezithile zasendle; ezinyaweni zakhe kukhona ikherubi elinamaphiko avulekile njengeshalofu. Kusuka endaweni enesiphambano ezinye izinto ezibunjiwe zehla ngokunyakaza okukhulu, zakha uhlobo lwendwangu eNcasakazini, ezinhlangothini zayo ongabona izibani zamazulu ezifana nezindonga, enye inenyanga enye ilanga.
