Ukuba khona kwabaseSpain, ekupheleni kwekhulu le-16, endaweni lapho idolobha laseSan Luis Potosí kumi khona manje, kuphendulwe ngezizathu zamasosha, kwanikezwa impi abantu bomdabu baseGuachichil abayibonisa.
AbaseSpain babanqobile base bebahlanganisa kabusha edolobheni laseSan Luis ukuze babalawule kangcono, kodwa futhi baletha nebutho lamaTlaxcalans elalihlala eMexquitic. Ngokutholakala kwezimayini zaseSan Pedro ngo-1592 kanye nokuthuthukiswa kwezimayini okwalandela, abavukuzi baxoxisana noJuan de Oñate nabomdabu ukuba bayohlala ethafeni laseSan Luis Mexquitic, kamuva iSan Luis Minas del Potosí, lapho bafake khona inzuzo haciendas namakhaya abo. Idolobha elisha, elalizokwaziwa kanjalo maphakathi nekhulu leshumi nesikhombisa, lathola uhlaka olufanayo lwezindawo zokuhlala zaseSpain eMelika: igridi yamabhodi okuhlola, nesikwele esikhulu maphakathi nesonto elikhulu kanye nezindlu zasebukhosini ezinhlangothini zalo. Kepha ngenxa yokwakhiwa kwamasonto amakhulu nezindawo zezindela, kanye nokuba khona kwezigodi zezimayini neminye imifudlana yamanzi, ukunwetshwa kwedolobha kwadingeka kudele ukujwayeleka kwemigwaqo yalo, ukuze bangaphandle komkhakha ophakathi nendawo. Aziqondile noma zinobubanzi obufanayo, okunikeza ukubukeka kwasekuqaleni kakhulu eSan Luis Potosí.
Ngokungafani namanye amadolobha anezimayini, njengeGuanajuato noma iZacatecas, ukungajwayelekile eSan Luis akufiki nokho, kumlingiswa we-labyrinthine. Njengakwamanye amadolobha amakoloni eMexico, ukuchuma kwezimayini nezentengiselwano ngasekupheleni kwekhulu le-17 nasekuqaleni kwekhulu le-18 kwaholela ekwakhiweni kabusha kwezakhiwo eziyinhloko zenkolo, njengethempeli kanye nesigodlo saseSan Francisco (okumanje sigcina iMuseo Regional Potosino ), lapho kwanezelwa khona isonto lase-Aranzazú neThempeli le-Third Order, kanye nesonto elidala kanye nesonto elikhulu lamanje, okwathi ngekhulu le-19 laqhubeka nokuthola imisebenzi emisha yokuhlobisa, nendlu engcwele yaseGuadalupe, kusukela engxenyeni yokugcina ye Ikhulu le-18, umsebenzi womakhi uFelipe Cleere. Futhi kusukela ngesikhathi nangombhali ofanayo isakhiwo esidala seCajas Reales, phambi kwesikwele.
Kusukela ngasekupheleni kwekhulu leminyaka kanye nakuMiguel Constanzó odumile (umbhali webhilidi lakwaCitadel eMexico City) kukhona amaRoyal Houses, njengamanje iNdlu KaHulumeni. Isibonelo esihle sezakhiwo zomphakathi yindlu ka-Ensign Manuel de la Gándara. Elinye lamathempeli okoloniyali, elika-El Carmen, kusukela maphakathi nekhulu le-18, likhombisa ingilazi ehehayo ehehayo enezinsika zikaSolomon (ezijikelezayo) ezizungezwe imigexo yezimbali yamatshe. Ama-altare ayo egolide (ngaphandle kwelikhulu) angamanye alawa asinda kuleli dolobha ekushintsheni kwezemfashini okwathi, ekupheleni kweKoloni, kwawafaka ama-neoclassical.
Izindlu ezindala zaseSan Luis zinikela ngezibonelo ezinhle kakhulu zamatshe ezinsikeni zawo nasemaphalazini. Ukuqhubeka nempilo eMexico ekupheleni kwesikhathi samakoloni nasekuqaleni kwenkathi ezimele, kwenze ukwakhiwa kwezakhiwo zomphakathi kuthola ukubaluleka okukhulayo nakuleli dolobha. Umakhi odumile uFrancisco E. Tresguerras waklama iphrojekthi yeCalderón Theatre emashumini okuqala ekhulu le-19, ngaphakathi kwesitayela se-neoclassical esivelele saleyo minyaka. Ngesikhathi esifanayo kwakhiwa Ikholomu lesikwele futhi kwakhiwa umsele wamanzi weCañada del Lobo, neBhokisi Lamanzi elihle kakhulu, umsebenzi kaJuan Sanabria, okhomba iSan Luis Potosí. Ngesikhathi sePorfiriato iTheatre yaseLa Paz yakhiwa, ngomlingiswa ovelele nesifanekiselo esilinganayo sedolobha, umsebenzi kaJosé Noriega.
