I-Christianization ye-Yaquis yiyo eyavumela inkolo ukuthi isabalale ngo-1609, ingene endaweni yaseSonora.
Ngesikhathi seColony, uSonora wayehambisana kuphela nemithambeka yeSierra Madre Occidental efakwe emikhawulweni yalelo bhizinisi. Isifunda esasingena ngasenyakatho sisuka eMfuleni iYaqui, kufaka phakathi iReal de la Cieneguilla, sasibizwa ngePimería Baja kanye nesifunda esisenyakatho sisuka kuleyo Real kuya eMfuleni iColorado - esivele isesimweni samanje saseNyakatho Melika i-Arizona - sasibizwa ngePimería Alta.
Indawo yamanje yeSonoran ifaka nesifunda esincane eningizimu-ntshonalanga yalokho okwakuthiwa yiPimería ngaleso sikhathi, esifundeni saseChihuahua nase-Ostimuri, indawo esemaphethelweni eGulf of California, phakathi kwemifula iMayo neYaqui.
Ngo-1614 izithunywa zevangeli uPérez de Rivas noPedro Méndez benza amaKrestu abe ngamaKrestu endaweni yase-Ostimuri, bahlukanisa imishini yaba iziFunda ezintathu: iSanta Cruz (emlonyeni weMayo), uNavojoa noTesia.
AbakwaTepahues bahlanganiswa kanye neCornicaris ngo-1620. UFata Miguel Godínez wasungula imishini yeSan Andrés de Cornicari ne-Asunción de Tepahui . Ngawo lowo nyaka kwasungulwa iRectorate of San Ignacio, eyayihlanganisa, ngaphezu kwemishini emihlanu eshiwo ngaphambili, leyo yaseBacúm, Torín neRahún, esemlonyeni weYaqui.
Ngo-1617 amaYaquis aguqulwa ngabazali uPérez de Rivas noTomás Basilio. Yize behlushwa imibhikisho, izibhelu, ukuhlukunyezwa nokubulawa kwabantu, ukuguqulwa kukaSonora kwakushesha futhi kunamandla. Ngekhulu le-17 amaJesuit andisa futhi asungula imishini kaMaycoba neYecora engxenyeni eseningizimu-ntshonalanga yalokho abakwaziyo njengeChínipas.
Ohambweni olusuka eMfuleni iYaqui luya enyakatho lwahlukaniswa lwaba amakholiji amane: iSan Borja eyodwa yahlanganisa ukuthunywa kwe: Cucumaripa neTecoripa , eyasungulwa ngo-1619; UMovas no-Onovas, ngo-1622; ISahuaripa ngo-1627; IMatape ngo-1629; Onapa ngo-1677 no-Arivechi , ngo-1727. I-Rectorate of the Holy Holy Martyrs of Japan eyayihlanganisa iBatuco eyasungulwa ngo-1627, i-Oposura ngo-1640 neBacadeguachi , IGuazavas , USanta María Baceraca noSan Miguel Bavispe , futhi yasungulwa ngo-1645. Futhi noRectorate waseSan Javier owahlanganisa ukuthunywa kwe-Ures ngo-1636; I-Aconchi, i-Opodepe neBanámichi ngo-1639; ICucurpe ne-Arizpe ngo-1648, neCuaquiárachi ngo-1655.
Ngo-1687 isithunywa sevangeli u-Eusebio Francisco Kino wangena ePimería Alta futhi waqala imishini yeRectorate of Nuestra Señora de los Dolores, eyasungula: Caborca, okwabelwa kuyo uFrancisco Javier Saeta ogcina izincwadi ezisekelwa nguye ngokomoya I-Kino; Atil, Tubutama, Our Lady of Sorrows from Saric, Pitiquito, Aiil, Oquitoa, Magdalena, San Ignacio, Cocóspera kanye ne-Imuris.
Ngemuva kokuxoshwa kwamaJesuit, ohambweni babephethe amaFranciscans, angazange akhe futhi azinqumela ekuzameni ukugcina lawo akhona. Lapho amaJesuit esevele esezakhele izindawo zokuhlala eSinaloa naseSonora, aphendula amehlo abheka endaweni yaseCalifornia.
