IColegio de San Juan de Letrán yaqala ngokuzibiza ngo "Colegio para mestizos" futhi yadalwa ngonyaka we-1548, ngokuthathelwa ngabaseSpain abanenhlonipho ababona ukwanda kwenani lamamestizo azalwa eNew Spain adinga imfundo.
IColegio de San Juan de Letrán yaqala ngokuzibiza ngo- “Colegio para mestizos” futhi yadalwa ngonyaka we-1548, ngokuthathelwa izinyathelo ngabaseSpain abanenhlonipho ababona ukwanda kwenani labamestizo abazalwa eNew Spain abadinga imfundo.
Ukuze bathole lesi sikhungo, abacelanga imvume kuViceroy Antonio de Mendoza, kepha bathumela ummeleli eSpain ukuyothola imvume yenkosi, kwathi uDon Gregorio de la Pesquera waqokelwa lo msebenzi. Lo muntu ophethe wathola iSitifiketi Sasebukhosini sokugunyazwa esakhishwa ngo-Agasti 18, 1548. Ekuqaliseni kwayo, iKolishi lathola umdlalo wama-peso ayizinkulungwane ezingama-600 ezimayini, iminikelo yangasese kanye neminikelo.
Wayeholwa ngabapristi abathathu: umphathi kanye namakhansela amabili, umphathi wayengakwazi ukuhlala unyaka esikhundleni sakhe bese kuthi laba abanye babambe isikhundla sobukhosi. Ukufunda, kufundiswa imfundiso yobuKrestu, bese kuthi abafundi abathuthuke kakhulu bakhuthazwe ukuthi baye eyunivesithi.
Isikole senqabile ekupheleni kwekhulu le-18, sasinda kwaze kwaba yi-Independence kwathi ngo-1821 sathola umfutho omkhulu kodwa sanyamalala unomphela ngo-1857. SasiseCalle de San Juan de Letrán esidala phakathi kweCalle Venustiano Carranza neMadero eseduze komgwaqo Ibheke empumalanga phambi kwesigodlo saseSan Francisco esasihlala kuwo wonke umgwaqo.
